To induce differentiation, 2-day postconfluent 3T3-L1 preadipocytes day 0 were stimulated for 48 h with 0. To verify whether monacolin K inhibited adipogenesis, we cultured cells in the presence or absence of lovastatin at the indicated concentrations and examined the intracellular TG content.
On day 10 of the GSPE treatment, all the rats were killed at hours by beheading and the blood was collected using heparin as the anticoagulant. The vehicle control was 0. Introduction Obesity is a chronic disorder of carbohydrate and lipid metabolism and is characterized by an increased fat deposition in adipose tissue and other internal organs [ 1 ].
On the basis of the 3-d intake and excretion data, apparent fat absorption was calculated using the following formula: Abstract The present study was undertaken to explore the effect of piperine in obesity-induced dyslipidemia.
In the face of this unmet medical need, there is requirement of new potential antiobesity drug to combat this syndrome. The results showed that cells treated with RMR-W exhibited moderate lipolysis activity accompanied by less cellular TG than the control cells.
This article has been cited by other articles in PMC. Perirenal and epididymal fat pads were removed and weighed. Shreya Shah, E-mail: Therefore, the suppressive property of the RMR extracts in 3T3-L1 preadipocyte proliferation may have been the result of growth retardation instead of cytotoxicity.
Table 2: It appears that the inhibitory effect of RMR on appetite is related to the monacolin K component. Protein bands were stained with Coomassie Brilliant Blue R in methanol-acetic acid-water 5: It was noted that the cells became round and detached from the culture dishes in the presence of higher concentrations of RMR-E Figure 2d.
Specific Taqman probes Applied Biosystems were used for different genes.
Furthermore, RMR treatment reduced the hyperinsulinemia induced by the HF diet without affecting the blood glucose level.
Consumption of the HF diet resulted in a decrease in food consumption; however, energy intake in the HF group was High-carbohydrate High-fat Diet –induced Metabolic Syndrome and Cardiovascular Remodeling in Rats.
cardiovascular disease, hypertension, dyslipidemia, high-carbohydrate, high-fat diet Search for Similar Articles You may search for similar articles that contain these same keywords or you may modify the keyword list to augment your search.
Jul 07, · GSPE treatment prevents dyslipidemia induced by high-fat diet. The body weight of rats fed with an HFD was significantly higher (approximately 40%) than those in the control group ().After 13 Cited by: Nov 03, · In this study, we examined the role of miR in the cardiac and metabolic alterations promoted by high fat (HF) diet.
We found that loss of miR attenuated the gain of fat mass and prevented dyslipidemia induced by HF diet, although the body weight gain, or glucose intolerance and insulin resistance did not seem to be criativabrasilia.com by: 3.
Apr 29, · The correlation found between dyslipidemia and oxidative stress in this study shows that dyslipidemia induced by ingestion of high fat diet is the primary cause of lipid peroxidation. Therefore, the possible reason for improvement in dyslipidemia with AqE-TFG may be due to reduction in oxidative stress in HFD fed rats.
Objective. We previously found that lipoic acid (LA) improved high-fat diet (HFD)–induced dyslipidemia in rats. To elucidate the molecular mechanisms of that effect, we carried out experiments aimed at analyzing biochemical parameters and gene expression criativabrasilia.com by: Sep 16, · Red mold rice prevents the development of obesity, dyslipidemia and hyperinsulinemia induced by high-fat diet Skip to main content Thank you for visiting criativabrasilia.com by: